Professor Philho Lee was the first in the world to extend the Buchner reaction to non-benzenoid aromatic compounds, later publishing his findings in Nature Communications. This extension, achieved through the enlargement of the five-membered ring in azulene, led to the synthesis of fused 6,7-membered bicyclic compounds. This represented a new strategy for selective synthesis, and has contributed significantly to expanding the scope of functionalization reactions in non-benzenoid aromatic compounds, particularly via the numerous related papers published by Professor Lee.
In 2013, he pioneered the use of phosphoryl groups as directing groups in carbon-hydrogen (C-H) bond activation reactions, developing an innovative synthesis method for various phosphaheterocycles. He has since led research in this field.
Recently, he has been focusing on boron-hydrogen (B-H) bond activation reactions using transition metal catalysts, and has dedicated his efforts to developing stereo- and regioselective synthesis methods for boron cluster compounds.
As a researcher, Professor Lee has played a crucial role in the technical advancement of catalytic organic reactions for the past 33 years, greatly contributing to the development of basic science and fine chemical industries in Korea.
He has published 241 SCI papers and achieved an H-index of 50 (WOS), making outstanding contributions to the development of organic synthesis methodology domestically and internationally. He has also devoted himself to nurturing talent, producing many new scholars, and helping to cultivate specialized personnel in fine chemistry.