Development of Dark-Field Single-Molecule PRET Hyperspectral Imaging Technology for Real-Time Super-Resolution Observation of Intracellular Quantum Electron Transfer Dynamics
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Affiliation
Seoul National University Department of Applied Bioengineering
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E-Mail
jeomik@snu.ac.kr
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Award-winning achievements
In quantum biology, research on electron transfer phenomena has primarily focused on theoretical approaches, while experimental verification and visualization has been extremely rare. This study aims to develop Plasmon Resonance Energy Transfer (PRET)-based single-molecule spectroscopic imaging technology that can measure quantum electron transfer in living cells in real time and with high sensitivity.
The project proposes an innovative methodology for visualizing the electron transfer states of biomolecules using single-molecule localization microscopy, a super-resolution imaging technique. It aims to validate and introduce original technology that will dramatically improve the measurement speed of conventional large-area spectroscopic signals.
This technology is expected to be applied in various fields, such as bacterial communication, quantum medicine, and intracellular redox dynamics research, where it will make significant contributions to the elucidation of disease mechanisms and drug action mechanisms at the cellular organelle level.